Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Architecture of kinase's catalytic domain and molecular aspects of spirooxindole scaffold binding at the ATP canonical binding site. (A) Cartoon/surface 3D-representation of the conserved folded tertiary architecture of an example kinase biotarget; CDK2 (PDB_ID: 1qmz ) in complex with ATP molecule (orange sticks), Mg +2 ion (green sphere) and protein substrate (cartoon). Key kinase structural motifs and secondary structures are color-coded. The amino and carboxy-termini are denoted with letters N and C, respectively; (B) Detailed ATP-binding site showing the four main sub-pockets (①–④) for the recognition and binding to main scaffolds of the small molecule kinase inhibitors: (C) key pharmacophoric features of reported small molecule kinase inhibitors and the quite superimposition of the spirooxindole scaffolds over these features. Pharmacophoric features are shown in the 3D-spatial arrangement of color-coded meshed spheres (purple = hydrogen bond acceptor HAcc; blue = hydrogen bond donor HDo, and orange = aromatic rings Aro). Arrows denote the projection/directionality of the hydrogen bonds.

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques: Binding Assay

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole 16.

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthetic routes of spirooxindole derivatives (21a–l).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of di-spirooxindole derivatives (25a–n).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives (28a–m).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives (37a–g).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives (40a–c).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives (43a–o).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives (45a–o).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives 48a–l.

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives (8a–h).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of bi-spirooxindole derivatives 54a–o.

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques:

Journal: RSC Advances

Article Title: Recent advances in the halogenated spirooxindoles as novel anticancer scaffolds: chemistry and bioactivity approach

doi: 10.1039/d5ra03404c

Figure Lengend Snippet: Synthesis of spirooxindole derivatives (60a–i).

Article Snippet: This makes halogenated spirooxindole very promising as a potential anticancer agent, either as a multitarget or selective kinase inhibitor.

Techniques: